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Gamma- hydroxybutyrate acid GHB , a GABA B receptor agonist approved for treatment of narcolepsy, impairs driving ability, but little is known about doses and plasma concentrations associated with impairment and time course of recovery. GHB blood samples were collected prior to and at one, three and six hours post dosing. Driving simulator sessions occurred immediately after blood sampling. Plasma GHB was not detectable at baseline or six hours post dosing.

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